Publications and reports

Below is a list of publications from Professor Sinclair and affiliated clinical colleagues since 2014, in chronological order.

Rodríguez-Mañas L, Sinclair AJ. ‘Frailty: the quest for new domains, clinical definitions and subtypes. Is this justified on new evidence emerging?’ J Nutr Health Aging. 2014 Jan;18(1):92-4.

Rodríguez-Mañas L, Bayer AJ, Kelly M, Zeyfang A, Izquierdo M, Laosa O, Hardman TC, Sinclair AJ, Moreira S, Cook J; MID-Frail Consortium. ‘An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes–the MID-Frail study: study protocol for a randomised controlled trial.’ Trials. 2014 Jan 24;15:34

Jabbari E, Sethuraman S, Sekaran L. ‘The clinical dilemma of treating transient ischaemic attack-like symptoms in patients with coexisting arteriovenous malformation.’ BMJ Case Rep. 2014 Mar 11;2014.

Hattersley AT, Marcovecchio ML, Chiarelli F, Silverstein J, Heller S, Damm P, Mathiesen ER, Zinman B, Sinclair A. ‘Lifecourse: management of type 1 diabetes.’ Lancet Diabetes Endocrinol. 2014 Mar;2(3):194-5.

Dunning T, Sinclair A, Colagiuri S. ‘New IDF Guideline for managing type 2 diabetes in older people. Diabetes Res Clin Pract’. 2014 Mar;103(3):538-40.

Rana KS, Arif M, Hill EJ, Aldred S, Nagel DA, Nevill A, Randeva HS, Bailey CJ, Bellary S, Brown JE. ‘Plasma irisin levels predict telomere length in healthy adults.’ Age (Dordr). 2014 Apr;36(2):995-1001.

Hackett G, Kirby M, Sinclair AJ. ‘Testosterone deficiency, cardiac health, and older men’. Int J Endocrinol. Apr 2014:143763.

Sinclair A, Bode B, Harris S, Vijapurkar U, Mayer C, Fung A, Shaw W, Usiskin K, Desai M, Meininger G. ‘Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies’. BMC Endocr Disord. 2014 Apr 18;14:37.

International Diabetes Federation Guideline Development Group. ‘Global guideline for type 2 diabetes’. Diabetes Res Clin Pract. 2014 Apr;104(1):1-52.

Aversa A, Donini LM, Bruzziches R, LaCava R, Mattace Raso F, Sinclair A. ‘Coordinating care aspects related to sexual health in the aging male’. Int J Endocrinol. Apr 2014;2014:653587.

McDonald HI, Nitsch D, Millett ER, Sinclair A, Thomas SL. ‘New estimates of the burden of acute community-acquired infections among older people with diabetes mellitus: a retrospective cohort study using linked electronic health records.’ Diabet Med. 2014 May;31(5):606-14.

Canevelli M, Adali N, Kelaiditi E, Cantet C, Ousset PJ, Cesari M; ICTUS/DSA Group. ‘Effects of Gingko biloba supplementation in Alzheimer’s disease patients receiving cholinesterase inhibitors: data from the ICTUS study’. Phytomedicine. 2014 May 15;21(6):888-92.

Abdelhafiz AH, Chakravorty P, Gupta S, Haque A, Sinclair AJ. ‘Can hypoglycaemic medications be withdrawn in older people with type 2 diabetes?’ Int J Clin Pract. 2014 Jun;68(6):790-2.

Jhita T, Petrou S, Gumber A, Szczepura A, Raymond NT, Bellary S. ‘Ethnic differences in health related quality of life for patients with type 2 diabetes. Health Qual Life Outcomes’. 2014 Jun 5;12:83.

Bellary S, Faint JM, Assi LK, Hutchison CA, Harding SJ, Raymond NT, Barnett AH. ‘Elevated serum free light chains predict cardiovascular events in type 2 diabetes.’ Diabetes Care. 2014 Jul;37(7):2028-30.

Burmeister A, Assi LK, Ferro CJ, Hughes RG, Barnett AH, Bellary S, Cockwell P, Pratt G, Hutchison CA. ‘The relationship between high-sensitivity CRP and polyclonal free light chains as markers of inflammation in chronic disease’. Int J Lab Hematol. 2014 Aug;36(4):415-24.

Sinclair AJ, Hillson R, Bayer AJ; National Expert Working Group. ‘Diabetes and dementia in older people: a Best Clinical Practice Statement by a multidisciplinary National Expert Working Group.’ Diabet Med. 2014 Sep;31(9):1024-31.

Morley JE, Malmstrom TK, Rodriguez-Mañas L, Sinclair AJ. ‘Frailty, Sarcopenia and Diabetes’.  December 2014. JAMDA 15 853-859.


Lloyd CE, Mughal S, Roy T, Raymond NT, O’Hare JP, Barnett AH, Bellary S. ‘What factors influence concordance with medications? Findings from the U.K. Asian Diabetes study’. Diabet Med. 2014 Dec;31(12):1600-9.

Formiga F, Ferrer A, Padrós G, CorbellaX, Cos L, Sinclair AJ, Rodriguez-Mañas L. ‘Diabetes Mellitus as a Risk Factor for Functional and Cognitive Decline in Very Old People: The Octabaix Study.’ JAMDA Volume 15, Issue 12, December 2014, Pages 924–928

Grotz C, Letenneur L, Bonsang E, Amieva H, Meillon C, Quertemont E, Salmon E, Adam S; ICTUS/DSA group. ‘Retirement age and the age of onset of Alzheimer’s disease: results from the ICTUS study’. PLoS One. 2015 Feb 25;10(2):e0115056.

Abdelhafiz AH, Rodríguez-Mañas L, Morley JE, Sinclair AJ. ‘Hypoglycemia in older people – a less well recognized risk factor for frailty.’ Aging Dis. 2015 Mar 10;6(2):156-67.

Sinclair AJ, Dunning T, Rodriguez-Mañas L. ‘Diabetes in older people: new insights and remaining challenges.’ Lancet Diabetes Endocrinol April 2015; 3: 275–85.

Brown A, Gouldstone A, Fox E, Field A, Todd W, Shakher J, Bellary S, et al. ‘Description and preliminary results from a structured specialist behavioural weight management group intervention: Specialist Lifestyle Management (SLiM) programme’. BMJ Open. 2015 Apr 8;5(4):e007217.

Scott AR; Joint British Diabetes Societies (JBDS) for Inpatient Care; JBDS hyperosmolar hyperglycaemic guidelines group. ‘Management of hyperosmolar hyperglycaemic state in adults with diabetes’. Diabet Med. 2015 Jun;32(6):714-24.

McDonald HI, Nitsch D, Millett ER, Sinclair A, Thomas SL. ‘Are pre-existing markers of chronic kidney disease associated with short-term mortality following acute community-acquired pneumonia and sepsis? A cohort study among older people with diabetes using electronic health records’. Nephrol Dial Transplant. 2015 Jun;30(6):1002-9.

Erusalimsky JD, Grillari J, Grune T, Jansen-Duerr P, Lippi G, Sinclair AJ, Tegnér J, Viña J, Durrance-Bagale A, Miñambres R, Viegas M, Rodríguez-Mañas L. ‘In Search of ‘Omics’-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.’  Gerontology. 2015 Jul 23.

Abdelhafiz AH, Sinclair AJ. ‘Diabetes, Nutrition, and Exercise’. Clin Geriatr Med. 2015 Aug;31(3):439-51.

Abdelhafiz AH, Sinclair AJ. ‘Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor?’ Aging Dis. 2015 Aug 1;6(4):262-70.

Cesari M, Fielding R, Bénichou O, Bernabei R, Bhasin S, Guralnik JM, Jette A, Landi F, Pahor M, Rodriguez-Manas L, Rolland Y, Roubenoff R, Sinclair AJ, Studenski S, Travison T, Vellas B. ‘Pharmacological Interventions in Frailty and Sarcopaenia: Report by the International Conference on Frailty and Sarcopaenia research task force.’ J Frailty Aging. Sep 2015;4(3):114-120.

Lippi G, Jansen-Duerr P, Viña J, Durrance-Bagale A, Abugessaisa I, Gomez-Cabrero D, Tegnér J, Grillari J, Erusalimsky J, Sinclair A, Rodriguez-Manãs L; FRAILOMIC consortium. ‘Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative.’ Clin Chem Lab Med. 2015 Sep 1;53(10):e253-5.

Abbatecola AM, Paolisso G, Sinclair AJ. ‘Treating diabetes mellitus in older and oldest old patients.’ Curr Pharm Des. Nov 2015;21(13):1665-71.

Coley N, Gallini A, Garès V, Gardette V, Andrieu S; ICTUS/DSA group. ‘A Longitudinal Study of Transitions Between Informal and Formal Care in Alzheimer Disease Using Multistate Models in the European ICTUS Cohort.’ J Am Med Dir Assoc. 2015 Dec 1;16(12):1104.