Publications and papers

Professor Alan Sinclair Publications 2014-2017

Rodríguez-Mañas L, Sinclair AJ. Frailty: the quest for new domains, clinical definitions and subtypes. Is this justified on new evidence emerging? J Nutr Health Aging. 2014 Jan;18(1):92-4.

Rodríguez-Mañas L, Bayer AJ, Kelly M, Zeyfang A, Izquierdo M, Laosa O, Hardman TC, Sinclair AJ, Moreira S, Cook J; MID-Frail Consortium. An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes–the MID-Frail study: study protocol for a randomised controlled trial. Trials. 2014 Jan 24;15:34

Hattersley AT, Marcovecchio ML, Chiarelli F, Silverstein J, Heller S, Damm P, Mathiesen ER, Zinman B, Sinclair AJ Lifecourse: management of type 1 diabetes. Lancet Diabetes Endocrinol. 2014 Mar;2(3):194-5.

Dunning T, Sinclair AJ, Colagiuri S. New IDF Guideline for managing type 2 diabetes in older people. Diabetes Res Clin Pract. 2014 Mar;103(3):538-40.

Hackett G, Kirby M, Sinclair AJ. Testosterone deficiency, cardiac health, and older men. Int J Endocrinol. 2014 Apr:143763.

Sinclair A, Bode B, Harris S, Vijapurkar U, Mayer C, Fung A, Shaw W, Usiskin K, Desai M, Meininger G. Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord. 2014 Apr 18;14:37.

Aversa A, Donini LM, Bruzziches R, LaCava R, Mattace Raso F, Sinclair A. Coordinating care aspects related to sexual health in the aging male. Int J Endocrinol. 2014 Apr:653587.

McDonald HI, Nitsch D, Millett ER, Sinclair A, Thomas SL. New estimates of the burden of acute community-acquired infections among older people with diabetes mellitus: a retrospective cohort study using linked electronic health records. Diabet Med. 2014 May;31(5):606-14.

Abdelhafiz AH, Chakravorty P, Gupta S, Haque A, Sinclair AJ. Can hypoglycaemic medications be withdrawn in older people with type 2 diabetes? Int J Clin Pract. 2014 Jun;68(6):790-2.

Sinclair AJ, Hillson R, Bayer AJ; National Expert Working Group. Diabetes and dementia in older people: a Best Clinical Practice Statement by a multidisciplinary National Expert Working Group. Diabet Med. 2014 Sep;31(9):1024-31.

Morley JE, Malmstrom TK, Rodriguez-Mañas L, Sinclair AJ. Frailty, sarcopenia and diabetes. J Am Med Dir Assoc. 2014 Dec;15(12):853-9

Formiga F, Ferrer A, Padrós G, CorbellaX, Cos L, Sinclair AJ, Rodriguez-Mañas L. Diabetes Mellitus as a Risk Factor for Functional and Cognitive Decline in Very Old People: The Octabaix Study. JAMDA 2014 Dec;15(12): 924–928

2015

Abbatecola AM, Paolisso G, Sinclair AJ. Treating diabetes mellitus in older and oldest old patients.

Curr Pharm Des. 2015;21(13):1665-71.

Abdelhafiz AH, Rodríguez-Mañas L, Morley JE, Sinclair AJ. Hypoglycemia in older people – a less well recognized risk factor for frailty. Aging Dis. 2015 Mar 10;6(2):156-67.

Sinclair AJ, Dunning T, Rodriguez-Mañas L. Diabetes in older people: new insights and remaining challenges. Lancet Diabetes Endocrinol 2015 April;3:275–85.

McDonald HI, Nitsch D, Millett ER, Sinclair A, Thomas SL: Are pre-existing markers of chronic kidney disease associated with short-term mortality following acute community-acquired pneumonia and sepsis? A cohort study among older people with diabetes using electronic health records. Nephrol Dial Transplant. 2015 Jun;30(6):1002-9.

Erusalimsky JD, Grillari J, Grune T, Jansen-Duerr P, Lippi G, Sinclair AJ, Tegnér J, Viña J, Durrance-Bagale A, Miñambres R, Viegas M, Rodríguez-Mañas L. In Search of ‘Omics’-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.  Gerontology. 2015 Jul 23;62(2):182-90.

Abdelhafiz AH, Sinclair AJ. Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor? Aging Dis. 2015 Aug 1;6(4):262-70

Abdelhafiz AH, Sinclair AJ. Diabetes, Nutrition, and Exercise. Clin Geriatr Med. 2015 Aug;31(3):439-51.

Cesari M, Fielding R, Bénichou O, Bernabei R, Bhasin S, Guralnik JM, Jette A, Landi F, Pahor M, Rodriguez-Manas L, Rolland Y, Roubenoff R, Sinclair AJ, Studenski S, Travison T, Vellas B. Pharmacological Interventions in Frailty and Sarcopaenia: Report by the International Conference on Frailty and Sarcopaenia research task force. J Frailty Aging. 2015 Sep;4(3):114-120.

Lippi G, Jansen-Duerr P, Viña J, Durrance-Bagale A, Abugessaisa I, Gomez-Cabrero D, Tegnér J, Grillari J, Erusalimsky J, Sinclair A, Rodriguez-Manãs L; FRAILOMIC consortium. Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative. Clin Chem Lab Med. 2015 Sep 1;53(10):e253-5.

Sinclair AJ. Frailty and Sarcopaenia Trials in Primary Care – Identifying and Overcoming Key Barriers to Successful Clinician Participation. J Frailty Aging. 2015 Sep;4(3):129-30.

2016

Tomlin A, Sinclair A. The influence of cognition on self-management of type 2 diabetes in older people. Psychol Res Behav Manag. 2016 Jan 21;9:7-20

Abizanda P, Sinclair A, Barcons N, Lizán L, Rodríguez-Mañas L. Costs of Malnutrition in Institutionalized and Community-Dwelling Older Adults: A Systematic Review. J Am Med Dir Assoc. 2016 Jan;17(1):17-23.

Bunn F, Goodman C, Malone JR, Jones PR, Burton C, Rait G, Trivedi D, Bayer A, Sinclair A. Managing diabetes in people with dementia: protocol for a realist review. Syst Rev. 2016 Jan 7;5:5.

Sinclair AJ, Rodriguez-Mañas L; Diabetes and Frailty: Two Converging Conditions? Can J Diabetes. 2016 Feb;40(1):77-83

Abdelhafiz AH, Koay L, Sinclair AJ. The effect of frailty should be considered in the management plan of older people with Type 2 diabetes. Future Sci OA. 2016 Feb 12;2(1):FSO102.

Sinclair AJ, Bode B, Harris S, Vijapurkar U, Shaw W, Desai M, Meininger G. Efficacy and Safety of Canagliflozin in Individuals Aged 75 and Older with Type 2 Diabetes Mellitus: A Pooled Analysis. J Am Geriatr Soc. 2016 Mar;64(3):543-52

Hackett G, Heald AH, Sinclair A, Jones PW, Strange RC, Ramachandran S. Serum testosterone, testosterone replacement therapy and all-cause mortality in men with type 2 diabetes: retrospective consideration of the impact of PDE5 inhibitors and statins. Int J Clin Pract. 2016 Mar;70(3):244-53

Cesari M, Prince M, Thiyagarajan JA, De Carvalho IA, Bernabei R, Chan P, Gutierrez-Robledo LM, Michel JP, Morley JE, Ong P, Rodriguez Manas L, Sinclair A, Won CW, Beard J, Vellas B. Frailty: An Emerging Public Health Priority. J Am Med Dir Assoc. 2016 Mar 1;17(3):188-92

Forbes A, Murrels T, Sinclair AJ. Examining factors associated with excess mortality in older people (age ≥ 70 years) with diabetes – a 10-year cohort study of older people with and without diabetes. Diabetes Med. 2016 Apr;17.

de Souto Barreto P, Morley JE, Chodzko-Zajko W, H Pitkala K, Weening-Djiksterhuis E, Rodriguez-Mañas L, Barbagallo M, Rosendahl E, Sinclair A, Landi F, Izquierdo M, Vellas B, Rolland Y. Recommendations on Physical Activity and Exercise for Older Adults Living in Long-Term Care Facilities: A Taskforce Report. International Association of Gerontology and Geriatrics – Global Aging Research Network (IAGG-GARN) and the IAGG European Region Clinical Section. J Am Med Dir Assoc. 2016 May 1;17(5):381-92.

Sinclair AJ, Bellary S. Preventing hypoglycaemia: an elusive quest. Lancet Diabetes Endocrinol. 2016 Aug;4(8):635-6

Izquierdo MRodriguez-Mañas LCasas-Herrero AMartinez-Velilla NCadore ELSinclair AJ. Is It Ethical Not to Prescribe Physical Activity for the Elderly Frail? J Am Med Dir Assoc. 2016  Sep 1;17(9):779-81

Castro-Rodríguez M, Carnicero JA, Garcia-Garcia FJ, Walter S, Morley JE, Rodríguez-Artalejo F, Sinclair AJ, Rodríguez-Mañas L. Frailty as a Major Factor in the Increased Risk of Death and Disability in Older People With Diabetes. J Am Med Dir Assoc. 2016 Oct 1;17(10):949-55.

Abdelhafiz AH, Koay L, Sinclair AJ. The Emergence of Frailty May Lead to a State of Burnt out Type 2 Diabetes. J Frailty Aging. 2016 Oct;5(3):162-7

Abdelhafiz AH, McNicholas E, Sinclair AJ. Hypoglycemia, frailty and dementia in older people with diabetes: Reciprocal relations and clinical implications. J Diabetes Complications. 2016 Nov – Dec;30(8):1548-1554

2017

Gordon J, McEwan P, Evans M, Puelles J, Sinclair A.Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes. Diabetes Obes Metab. 2017 May;19(5):644-653

Laffon de Mazières C, Morley JE, Levy C, Agenes F, Barbagallo M, Cesari M, De Souto Barreto P, Donini LM, Fitten J, Franco A, Izquierdo M, Kane RA, Martin FC, Onder G, Ouslander J, Pitkälä K, Saliba D, Sinclair A, Manas LR, Vellas B, Rolland Y. Prevention of Functional Decline by Reframing the Role of Nursing Homes?

J Am Med Dir Assoc. 2017 Feb 1;18(2):105-110.

Landi F, Cesari M, Calvani R, Cherubini A, Di Bari M, Bejuit R, Mshid J, Andrieu S, Sinclair AJ, Sieber CC, Vellas B, Topinkova E, Strandberg T, Rodriguez-Manas L, Lattanzio F, Pahor M, Roubenoff R, Cruz-Jentoft AJ, Bernabei R, Marzetti E; SPRINTT Consortium.

The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. Aging Clin Exp Res. 2017 Feb;29(1):89-100.

Recently Accepted

Bakrania K, Yates T, Edwardson CL, Bodicoat DH, Esliger DW, Gill JM, Kazi A, Velayudhan L, Sinclair AJ, Sattar N, Biddle SJ, Hamer M, Davies MJ, Khunti K. Associations of moderate-to-vigorous-intensity physical activity and body mass index with glycated haemoglobin within the general population: a cross-sectional analysis of the 2008 Health Survey for England. BMJ Open. 2017 Apr 3;7(4)

Sinclair AJ, Abdelhafiz AH, Rodríguez-Mañas L. Frailty and sarcopenia – newly emerging and high impact complications of diabetes. J Diabetes Complications. 2017 May 12. pii: S1056-8727(17)30549-4.

Heller SR, Pratley RE, Sinclair A, Festa A, Kiljanski J, Brusko CS, Duan R, Heine RJ.

Glycaemic outcomes of an Individualised treatMent aPproach for oldER vulnerable patIents: A randomised, controlled stUdy in type 2 diabetes Mellitus (IMPERIUM). Diabetes Obes Metab. 2017 Aug 8.

Related Papers

Jabbari E, Sethuraman S, Sekaran L. The clinical dilemma of treating transient ischaemic attack-like symptoms in patients with coexisting arteriovenous malformation. BMJ Case Rep. 2014 Mar 11;2014.

Rana KS, Arif M, Hill EJ, Aldred S, Nagel DA, Nevill A, Randeva HS, Bailey CJ, Bellary S, Brown JE. Plasma irisin levels predict telomere length in healthy adults. Age (Dordr). 2014 Apr;36(2):995-1001.

International Diabetes Federation Guideline Development Group. Global guideline for type 2 diabetes. Diabetes Res Clin Pract. 2014 Apr;104(1):1-52.

Canevelli M, Adali N, Kelaiditi E, Cantet C, Ousset PJ, Cesari M; ICTUS/DSA Group. Effects of Gingko biloba supplementation in Alzheimer’s disease patients receiving cholinesterase inhibitors: data from the ICTUS study. Phytomedicine. 2014 May 15;21(6):888-92.

Jhita T, Petrou S, Gumber A, Szczepura A, Raymond NT, Bellary S. Ethnic differences in health related quality of life for patients with type 2 diabetes. Health Qual Life Outcomes. 2014 Jun;5;12:83

Bellary S, Faint JM, Assi LK, Hutchison CA, Harding SJ, Raymond NT, Barnett AH. Elevated serum free light chains predict cardiovascular events in type 2 diabetes. Diabetes Care. 2014 Jul;37(7):2028-30

Burmeister A, Assi LK, Ferro CJ, Hughes RG, Barnett AH, Bellary S, Cockwell P, Pratt G, Hutchison CA. The relationship between high-sensitivity CRP and polyclonal free light chains as markers of inflammation in chronic disease. Int J Lab Hematol. 2014 Aug;36(4):415-24.

Lloyd CE, Mughal S, Roy T, Raymond NT, O’Hare JP, Barnett AH, Bellary S. What factors influence concordance with medications? Findings from the U.K. Asian Diabetes study. Diabet Med. 2014 Dec;31(12):1600-9.

Grotz C, Letenneur L, Bonsang E, Amieva H, Meillon C, Quertemont E, Salmon E, Adam S; ICTUS/DSA group. Retirement age and the age of onset of Alzheimer’s disease: results from the ICTUS study. PLoS One. 2015 Feb 25;10(2):e0115056.

Brown A, Gouldstone A, Fox E, Field A, Todd W, Shakher J, Bellary S, et al. Description and preliminary results from a structured specialist behavioural weight management group intervention: Specialist Lifestyle Management (SLiM) programme. BMJ Open. 2015 Apr 8;5(4):e007217.

Scott AR; Joint British Diabetes Societies (JBDS) for Inpatient Care; JBDS hyperosmolar hyperglycaemic guidelines group. Management of hyperosmolar hyperglycaemic state in adults with diabetes. Diabetes Med. 2015 Jun;32(6):714-24.

Coley N, Gallini A, Garès V, Gardette V, Andrieu S; ICTUS/DSA group. ‘A Longitudinal Study of Transitions Between Informal and Formal Care in Alzheimer Disease Using Multistate Models in the European ICTUS Cohort.’ J Am Med Dir Assoc. 2015 Dec 1;16(12):1104.