Key publications

For a full list of publications involving Prof Alan Sinclair published between 2014 and 2017, click here.

Professor Alan Sinclair has been widely published in leading journals. These are his key papers with commentary:

Selected recent papers (n=6) Comment
Rodríguez-Mañas L, Sinclair AJ. ‘Frailty: the quest for new domains, clinical definitions and subtypes. Is this justified on new evidence emerging?’ J Nutr Health Aging. 2014 Jan;18(1):92-4. Commentary on the importance of detection of an objective assessment of frailty and the importance of this in improving quality of life and preventing disability.
Abdelhafiz AH, Sinclair AJ. ‘Diabetes, Nutrition, and Exercise’. Clin Geriatr Med. 2015 Aug;31(3):439-51. Review of the relationship between diabetes, ageing and sarcopaenia and, therefore, the importance of nutrition and exercise intervention in Older People with Diabetes.
Cesari M, Fielding R, Bénichou O, Bernabei R, Bhasin S, Guralnik JM, Jette A, Landi F, Pahor M, Rodriguez-Manas L, Rolland Y, Roubenoff R, Sinclair AJ, Studenski S, Travison T, Vellas B. ‘Pharmacological Interventions in Frailty and Sarcopaenia: Report by the International Conference on Frailty and Sarcopaenia research task force.’ J Frailty Aging. Sep 2015;4(3):114-120. Report from the International task force on Frailty and sarcopaenia, which discussed challenges related to drugs designed to target the biology of frailty and sarcopenia as well as more general questions about designing efficient drug trials for these conditions.
Sinclair AJ, Dunning T, Rodriguez-Mañas L. ‘Diabetes in older people: new insights and remaining challenges.’ Lancet Diabetes Endocrinol April 2015; 3: 275–85. Major review article published in the Lancet in the field of Diabetes and Older People, with key themes such as frailty and disability, the importance of a multidimensional and multidisciplinary assessment process, maintenance of independence, functional status, and quality of life, hypoglycaemia, and quality of diabetes care.
Sinclair AJ, Hillson R, Bayer AJ; National Expert Working Group. ‘Diabetes and dementia in older people: a Best Clinical Practice Statement by a multidisciplinary National Expert Working Group.’ Diabet Med. 2014 Sep;31(9):1024-31. A Best Clinical Practice statement for Dementia and Diabetes care which aims to provide a platform for further work in this area. This includes an integrated care pathway for both elements of this clinical relationship, guidance on identifying each condition and on dealing with the potentially hazardous issue of hypoglycaemia, and an outline of outlined important competencies required of healthcare workers in both medical/diabetes and mental health settings to enhance clinical care.

 

Morley JE, Malmstrom TK, Rodriguez-Mañas L, Sinclair AJ. ‘Frailty, Sarcopenia and Diabetes’.  December 2014. JAMDA 15 853-859. A review exploring the relationship between diabetes, sarcopaenia and frailty, and the clinical implications of such a relationship.