A new body of work
Led by Professor Alan Sinclair
Exploring the emerging importance of frailty
as a better-defined concept in ageing populations and its association with diabetes
Frailty and diabetes
The presence of frailty in a setting of diabetes increases the level of disability and leads to poorer clinical outcomes.

About Diabetes Frail:

Diabetes Frail was formed in June 2014 as a not-for-profit research organisation dedicated to learning more about frailty and its linkage with diabetes in older people. We have been the primary and leading site in Europe for studies in this emerging field.

A new body of research

Professor Alan Sinclair launched Diabetes Frail to further explore the emerging importance of frailty as a better-defined concept in ageing populations and its association with diabetes. Diabetes and frailty may be causally related and operate through each of the key components of the frailty phenotype or via the associated medical co-morbidities. The presence of frailty in a setting of diabetes increases the level of disability and leads to poorer clinical outcomes. The vascular complications of diabetes (both macro and microvascular) are implicated in this aetiopathogenesis of frailty and any associated mood disturbance or cognitive impairments worsen the outcome. Since March 2020, the work of Diabetes Frail has been severely hampered by the covid-19 outbreak which led to a suspension of related European Union-funded clinical trials connected with Diabetes Frail. However, Professor Sinclair has continued to be one of the leading UK diabetologists and has collaborate actively with his UK and European colleagues to publish nearly 20 research and review publications in 2020 as of October 2020 with two papers being published in Lancet Diabetes & Endocrinology. Future research, audit, clinical guideline development, and strategic healthcare development work will continue under the auspices of the Foundation for Diabetes Research in Older People (FDROP) which has been the academic arm of Diabetes Frail since 2015.


Portfolio of work

  • Current research projects

    To read about our the latest studies we are working on click here.
  • Publications and papers

    To view a comprehensive list of the research publications and papers which our Director, Professor Sinclair has led or, contributed to, click here.
  • Global Initiative in Diabetes for Older People

    Professor Alan Sinclair is leading a 'Global Initiative in Diabetes for Older People' on behalf of the International Association of Geriatrics and Gerontology (IAGG), to access the resources click here.
  • Care home diabetes education for clinicians and health care assistants

    Professor Sinclair can provide a fit-for-purpose, tailored and high-quality diabetes and educational platform on care home diabetes suitable for all grades of clinicians and care home staff, find out more here.
  • Reports and clinical guidelines

    To browse through the reports and clinical guidelines involving Professor Sinclair, click here.
  • International and national roles

    Our Director, Professor Sinclair holds a number of international and national roles, to read about them click here.
  • Collaborations

    Diabetes Frail and our Director, Professor Sinclair are involved in national and international research collaborations, to learn more click here.




Frailty and its relationship with diabetes

"Diabetes Frail is the world's first not-for-profit organisation devoted to the study of diabetes and related metabolic disease and the association with frailty", Professor Alan Sinclair